Pubblicazioni scientifiche

Excitatory/inhibitory imbalance in autism spectrum disorders: implication for interventions and therapeutics

Posted by on Feb 22, 2016 in Senza categoria | 0 comments

Scritto in  collaborazione con lo Spectrum Neurosciences Institute di New York, nostro gemello, identifica le aree per la Stimolazione Magnetica Transcranica ripetitiva (rTMS) e per la Stimolazione Elettrica (tDCS) nell’Autismo.     autism 2015 (4) (1)

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Better than treated as usual: Transcranial Magnetic Stimulation augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder, mini-review and pilot open-label trial

Posted by on Feb 9, 2016 in Senza categoria | 0 comments

Dalla collaborazione tra INS , Harvard ( NM)  e Alber Einstein NY (EH) ecco un lavoro che mostra come la TMS funzioni il doppio rispetto ai soliti trattamenti per il disturbo OCD resistente. Un bel passo avanti nella cura dell’ OCD .   J Psychopharmacol-2016-Pallanti-

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From psychopathology to neurocircuits: what we can learn from DBS? The case of obsessive-compulsive disorder

Posted by on Apr 20, 2015 in Senza categoria | 0 comments

(Dalla psicopatologia ai neurocircuiti: cosa possiamo apprendere dal DBS? Il caso del Disturbo Ossessivo-Compulsivo) Summary Objectives The aim of this review is to provide a brief summary of the existing data on the safety and effectiveness of deep brain stimulation (DBS) for treatment-resistant and treatment-refractory obsessive-compulsive disorder (OCD). Another purpose is to discuss the neurobiological mechanisms of DBS and their implications for the understanding of OCD neurobiology and its link to OCD psychopathology. In particular, we will focus on DBS of the nucleus accumbens because of the involvement of this area in the reward system, which seems to be impaired in OCD patients. Finally, we will provide a new psychopathological conceptualization of OCD. Methods Extensive review of the DBS literature for OCD patients was performed on PubMed. Results According to many neuroimaging studies, the neural circuit that seems to be most involved in OCD is the cortico-striatum-thalamus-cortical circuit (CSTC). Therefore, to date, five different components of this circuit have been tested as targets in DBS of OCD and show different efficacy: anterior limb of the internal capsule (ALIC), nucleus accumbens (Nacc), ventral capsule/ ventral striatum (VC/VS), subthalamic nucleus (STN) and the inferior thalamic peduncle (ITP). Conclusions DBS is a promising tool in the treatment of refractory OCD patients. The existing data show that the nucleus accumbens and the anterior limb of the internal capsule are the most promising targets for this treatment. Furthermore, DBS has shown new and interesting perspectives in the discovery of the neurobiological underpinnings of OCD. These new insights can provide a new psychopathological conceptualization of OCD, reconsidering this disorder as a primary anxiety disorder, rapidly moving as a behavioural addiction. However, further studies are needed to better clarify the long-term efficacy and safety of the procedure, and to better characterize the ideal patients that might have a good response to DBS.   From psychopathology to neurocircuits: what we can learn from DBS? The case of obsessive-compulsive...

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Streptococcal infections of skin and PANDAS

Posted by on Apr 17, 2015 in Senza categoria | 0 comments

Carelli R, Pallanti S. Group A streptococcal infections are associated with a variety of infections and a subset of obsessive-compulsive disorder and/or tic disorders. Screening of obsessive-compulsive symptoms and tics in patient with streptococcal infection of skin must be effective in identifying subjects who met published criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).   Dermatologic Therapy Volume 27, Issue 1, pages 28–30, January/February...

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Enhancing Cognitive-behavioral Therapy With Repetitive Transcranial Magnetic Stimulation in Refractory Obsessive-compulsive-disorder: A Case Report

Posted by on Apr 17, 2015 in Senza categoria | 0 comments

Grassi G, Godini L, Grippo A, Piccagliani D, Pallanti S. Exposure and response prevention therapy (ERP) is a cognitive-behavioral therapy (CBT) technique that is well established as first line treatment for obsessive compulsive disorder (OCD) [1]. The goal of exposure therapy is enhancing and facilitating patients’ fear extinction processes in front of the feared object, situation or thought/obsession. Several studies have tried to enhance fear extinction through pharmacological agents with mixed results [2]. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS), through its capacity to induce long-term potentiation, is able to modulate learning processes and hippocampal plasticity [3].   2014 Oct 18. pii: S1935-861X(14)00336-2. doi: 10.1016/j.brs.2014.10.007. [Epub ahead of...

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Pharmacological Treatments for Behavioral Addictions: From Behavioral Dimensions to the Research Domain Criteria Based Target

Posted by on Dic 11, 2014 in Senza categoria | 0 comments

Authors: S. Pallanti, G. Grassi, T. Tofani, S. Spitoni   Several patterns of maladaptive behaviors share their clinical features with those of substance use disorders such as tolerance, withdrawal, repeated unsuccessful attempts to cut back or quit, and interference in major areas of life function, thus gaining the name of “behavioral addictions”. Several studies showed that behavioral addictions and substance addictions share a similar pattern of brain activation during symptom provocation tasks, suggesting a common neurobiological substrate. However, despite the growing knowledge on the neurobiological underpinnings of behavioral addictions, treatment of these conditions is still controversial. Research Domain Criteria project would help in identifying circuitry involved in complex behavioral syndromes such as addiction either to substances or not-substances. The purpose of this review is to summarize current knowledge of the different pharmacological approaches to behavioral addictions. In particular, we will focus on the pharmacological treatment of pathological gambling, internet addiction and hypersexual disorder. Source: Current Psychopharmacology, Volume 2, Number 3, August 2013, pp....

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